- New data from the 15th European Epilepsy Congress reveals significant delays in diagnosing Lennox-Gastaut syndrome (LGS) and its heavy disease burden.
- LGS, a severe childhood epilepsy, often takes 12.3 months to diagnose.
- Despite multiple antiseizure medications, patients face persistent challenges, including comorbidities, cognitive impairments, and poor quality of life.
Mon Sep 09 04:00:46 -0000 2024 UTC– New data from the 15th European Epilepsy Congress reveals delays in diagnosing Lennox-Gastaut syndrome (LGS) and the disease’s significant impact on patients, UCB said Monday.
Multiple Medications
Patients face long waits for accurate diagnosis and struggle with treatment challenges despite taking multiple medications. The study underscores the necessity for new treatments addressing both seizures and non-seizure symptoms.
Lennox-Gastaut Syndrome
Lennox-Gastaut Syndrome (LGS) is a rare and severe form of epilepsy that typically begins in early childhood, usually between the ages of 3 and 5. It is characterized by multiple types of seizures, such as tonic (stiffening), atonic (drop attacks), and atypical absence seizures. LGS is often associated with cognitive impairments and developmental delays, making it one of the most challenging forms of epilepsy to treat.
Innovative Therapies
New treatments are needed to address both seizures and non-seizure symptoms. UCB emphasizes a multidisciplinary approach and introduces a new diagnostic tool to aid healthcare professionals. The findings underscore the need for innovative therapies for better long-term outcomes for LGS patients.
Comprehensive Care
Diagnostic tools are being developed to aid healthcare professionals in identifying LGS. UCB emphasizes the need for comprehensive care to manage the various aspects of LGS. While approved drugs provide some relief, there is a demand for more effective and sustainable therapies.
Causes of LSG
The exact cause of LGS can vary, with some cases linked to brain malformations, genetic disorders, or prior brain injuries, while others remain unexplained. The condition is marked by distinctive EEG patterns, particularly a slow spike-and-wave pattern, and is resistant to treatment. Patients often require a combination of medications, and other interventions like the ketogenic diet, vagus nerve stimulation (VNS), or surgery may be considered when seizures are difficult to control.
Managing LGS involves a multidisciplinary approach due to its complexity and the impact on both seizure control and cognitive development. Despite various treatment options, many individuals with LGS continue to experience frequent seizures and long-term developmental challenges, necessitating ongoing care and support
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